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RMU

Uruguayan Medical Journal

ISSN: 1688-0390


Vol.17 - Nº 3 - Dic. 2001

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Vaccination impact on infants at the Centro Hospitalario Pereira Rossell

MONTANO A; ALGORTA G; PÍREZ MC; PASCALE A; FARCILLI R; FERRARI AM
Rev Med Urug 2001; 17: 166-170
Full text (spanish) |  Full text (spanish) (New windows, pdf) | Abstract

Abstract

Uruguay was the first Latin American country to administer massive vaccination against Haemophilus influenzae b (Hib) with combined vaccination. A retrospective study of patients with invasive disease caused by Hib admitted to the Centro Hospitalario Pereira Rossell from 1993 to 1999 was performed to measure the impact of vaccination.

The annual distribution of the 74 patients with Hib was as follow: 31 in 1993, 34 in 1994, 5 during 1995 and one patient from 1996 to 1999.

The study included 58 case reports (78,4%), these infants were 1 to 36 months old.

Of them, 58,6% were younger than one year. Diagnoses were as follow: 42 cases of acute suppurative meningoencephalitis, 8 cases of pneumonia, multifocal accounted 4 cases, osteoarthritis 2 cases, and one patient with sepsis and one with bacteriemia.

At some time of the disease, 21 infants (36%) were sent to intensive care units. Five infants died. Of nine infants with invasive disease after massive vaccination, one was immunized (3 doses), another one had had one dosage according to its age and the rest were not immunized.

Vaccination has notably reduced incidence of invasive disease caused by Hib. This has led to a decrease in mortality and morbidity of diseases that produce severe sequels. It has also conduced to simplify management guidelines for frequent diseases like pneumonia and osteoarthritis.