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Uruguayan Medical Journal

ISSN: 1688-0390

Vol.20 - Nº 3 - Dic. 2004

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Encephalic non-seminomatous germinal tumors: five clinical case review

Rev Med Urug 2004; 20: 215-220
Full text (spanish) |  Full text (spanish) (New windows, pdf) | Abstract


Patients with non seminomatous germinal tumors usually present encephalic metastasis in 8%-15% of the cases, generally in the context of a systemic fallen again. Although the first choice in these cases is surgery, its chemiosensitivity indicates initial chemotherapy followed by radiotherapy with or without surgery. As in patients with other solid tumors, carriers with multiple injuries receive systemic treatment with or without radiotherapy.

Five patients aged from 20 and 43 years with encephalic non-seminomatous germinal tumors are analysed: two patients presented encephalic secondarism during diagnosis and two other patients during injury progress. Respecting the remaining case, its diagnosis was established during an extraencephalic parcial responce.

Coriocarcinoma and yolk sac tumors are the most frequent histologic variaties in this series. Four patients were at high risk, with extended lung commitment. Surgery was the first therapeutic manoeuvre in patients with secondarism. Benefits of systemic and radio combined treatment are highlighted in those who presented multiple encephalic injuries. Conclusions about survival could not be obtained due to the sample, but prognosis is not optimistic when encephalic secondarism is systemic treatment refractary.