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RMU

Uruguayan Medical Journal

ISSN: 1688-0390


Vol.23 - Nº 3 - Set. 2007

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Classic Enteropathogenic Escherichia coli (EPEC) associated with diarrhea in children users of the Hospital Pereira Rossell. Clinical aspects and characteristics of involved strains

VARELA G; JASINSKI C; GADEA MP; TANZI MN; MOTA MI; ARENAS C; PARDO L; GONZÁLEZ S; GONZÁLEZ G; SIROK A; SCHELOTTO F
Rev Med Urug 2007; 23: 153-163
Full text (spanish) |  Full text (spanish) (New windows, pdf) | Abstract

Abstract

Background: acute diarrhea disease (ADD) is responsible

of 12.000 deaths per day in Asia, Africa and Latin America.

Classic Enteropathogenic Escherichia coli (EPEC) is an

important virotype associated with ADD episodes in

children under five years of those regions.

Objectives: to know clinical manifestations of diarrhea

cases due to EPEC in children users of a Public Health

centre and to establish the characteristics of involved

strains.

Methods: ninety-five children with ADD were studied.

Every child underwent clinical history and copromi-crobiologic

studies. EPEC strains were detected by reaction

chain polymerase (PCR) of eae and were completely

characterized including determination of genetic variations

of eae and bfp genes.

Results: twenty-six EPEC strains were isolated, 15

typical and 11 atypical. The most frequent variant of bfp

was and 9 variants of eae were seen. Most of the infected

children with EPEC presented watery diarrhea associated

with vomiting, and fever in half of the cases. Blood and

fecal leukocytes were found in 20% of the children.

Conclusions: as it happens in other areas, typical EPEC

strains appear as frequent enteropathogens in this group

of children. Atypical cultures also play an important rol as

agents of diarrhea. Clinical characteristics do not differ

from those of children with diarrhea in developed

countries; no differences were seen with other agents.