Logotipo del SMU


Uruguayan Medical Journal

ISSN: 1688-0390

Vol.24 - Nº 1 - Mar. 2008

Previous Art | Index

Infectious agents entering the body by inhalation and its relevance in resolving the pathogenia of a few deep mycoses. Research in mice

Rev Med Urug 2008; 24: 56-61
Full text (spanish) |  Full text (spanish) (New windows, pdf) | Abstract


Knowing what potential access infectious agents have to the body is essential to, among other things, adopt the most suitable prophylactic measures in every case. This undoubtedly applies to mycoses, and especially deep systemic mycoses, given their severity. In the case of pulmonary entrance door the study included the classical clinical examination, as well as paraclinical studies such as radiology and skin tests of retarded hypersensitivity with the corresponding antigens.

Similarly, it has been acknowledged that experimental research in laboratory animals constitutes a relevant tool for making progress in the field. This study comprises a number of experiments carried out in Uruguay, where mice were used in order to investigate the feasibility of pulmonary entrance door for paracoccidioidomycosis (PCM), cryptococcosis and sporothricosis. These studies, pioneers in the field, have been of paramount importance for authors to accept that pulmonary entrance door is usual in both cryptococcosis and paracoccidioidomycosis, as it can also be a potential entrance door in cases of pulmoDr.

Ismael A. Conti Díaz 60 Revista Médica del Uruguay nary sporothricosis, which are often followed by hematic generalization.