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RMU

Uruguayan Medical Journal

ISSN: 1688-0390


Vol.29 - Nº 3 - Set. 2013

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ApoE polymorphisms and vascular damage in type 2 diabetics

GUERRA A; RAGGIO V; ESPERON P; FRAGA L; VALIÑO J; PISANO SÁNCHEZ A; PISANO RONDEAU A; MARTÍNEZ ROVIRA R; BORGIA F; SCHWEDT E; BELLOSO A; STOLL M
Rev Med Urug 2013; 29: 137-146
Full text (spanish) |  Full text (spanish) (New windows, pdf) | Abstract

Abstract

Introduction: apolipoproiten E (ApoE) is a constituent of plasma lipoproteins that plays an important role in metabolism acting as lipoprotein receptor ligand. Variations in the ApoE locus are associated to variations in concentration of low plasma density lipoproteins. Allele E4 has been associated to an increase of risk for cardiovascular disease, progress in diabetic nephropathies and severity and progression of diabetic neuropathies and retinopathies. Allele E2 is associated to conferring protection from coronary heart disease (CHD).

Objectives: to study the association between this polymorphism and the macroangiopathic effects, especially in terms of ischemic cardiopathy, and lipidogram in diabetic patients.

Method: 78 patients less than 85 years old with type 2 diabetes mellitus were studied, being the association between the ApoE polymorphism and the macroangiopathic and microangiopathic effects of diabetes assessed, as well as the lipidogram and age of patients at time of diagnosis. Genotype determination was done with standard extending-restricting methods following informed consent. Variables were analysed using Chi-scuared and the Fisher exact test. Alpha error rate was lower than 0.05.

Results: frequency of carriers of ApoE allele E4 among individuals with macroangiopathic complications was larger than among those who were free of these complications (26.2%), although differences were not statistically significant. The presence of ischemic heart disease was significantly associated with E4 allele, that is 56% versus 25%. The presence of the E4 allele was significantly associated to the diagnosis of diabetes earlier than 40 years old. Patients with risk alleles evidenced increased values of LDL and triglycerides.

Conclusions: allele E4 was associated with a larger risk for ischemic cardiopathy and age of diagnosing type 2 diabetes mellitus lower than 40 years old. The strong effect of genotype ApoE was evidence on the lipid profile of patients with type 2 diabetes.